

Weisz was born in Westminster, London, England, and grew up in Hampstead Garden Suburb. Her mother, Edith Ruth (née Teich), is a teacher turned psychotherapist who was born in Vienna, Austria. Her father, George Weisz, is a Hungarian-born inventor and engineer. Weisz's parents fled to England during World War II. Her father is Jewish and her mother has been described as either Catholic or Jewish (as well as "half-Italian"). Weisz was raised in a "cerebral Jewish household" and refers to herself as Jewish. Weisz has a sister, Minnie Weisz, who is an artist.
Weisz was educated privately at prestigious independent schools for girls: North London Collegiate School, Benenden School, and St Paul's Girls' School. She then entered Trinity Hall, Cambridge, where she graduated with a 2:1 in English. During her university years she appeared in various student productions, co-founding a student drama group called Cambridge Talking Tongues, which went on to win a Guardian Student Drama Award at the Edinburgh Fringe Festival for an improvised piece called Slight Possession.

Screen:
Having already worked for television productions, with parts in such major UK television series as Inspector Morse (1993), Weisz started her cinema career in 1995 with Chain Reaction and then appeared in Bernardo Bertolucci's Stealing Beauty. She followed this work with more English films including My Summer with Des, Swept from the Sea, The Land Girls, and Michael Winterbottom's I Want You. Although she received favourable critical recognition for her work to this point, her breakout into wide audience recognition came from a popular serio-comic horror movie The Mummy, in which she played the lead female role alongside Brendan Fraser. She followed this up with two hits, The Mummy Returns (2001), which grossed higher than the original, and About a Boy (2002) with Hugh Grant. Since then, her other film work has included Enemy at the Gates (2001), Runaway Jury (2003) and Constantine (2005).

The same year, she starred in The Fountain and also provided the voice for Saphira in the fantasy film Eragon. Her subsequent films include the Wong Kar-wai-directed drama My Blueberry Nights (in which she played an "anti-Southern belle") and director Rian Johnson's The Brothers Bloom, in which she plays a wealthy American woman targeted by two con man brothers (Adrien Brody, Mark Ruffalo). She plays the lead role of Hypatia of Alexandria in the historical drama film Agora, released in October 2009.

Her breakthrough role was that of Gilda in Welsh director Sean Mathias's 1995 West End revival of Noel Coward's 1933 play Design for Living at the Gielgud Theatre. Her other stage work includes the role of Catherine in a London production of Tennessee Williams' Suddenly Last Summer and Evelyn in Neil LaBute's The Shape of Things at the Almeida Theatre (also film) at its, then, temporary location in London's Kings Cross. In 2009 she played Blanche DuBois in a Donmar revival of A Streetcar Named Desire., Critics' Circle Theatre Award Best Actress 2009.
Other:
On 7 July 2007, Weisz presented at the American leg of Live Earth. She is represented by Independent Models in London.
Personal life:
Weisz is engaged to American filmmaker and producer Darren Aronofsky. They have been dating since 2001. They have a son, Henry Chance, born on 31 May 2006 in New York City. The couple reside in the East Village in Manhattan. Weisz also serves as a muse to fashion designer Narciso Rodriguez.